NEW FRONTIERS IN COAGULATION Thrombophilia and pregnancy
نویسنده
چکیده
Inherited and acquired thrombophilia are the main cause of thrombosis in pregnant women. A growing number of reports over the last years have suggested that these disorders are also associated with an increased incidence of vascular pathologies resulting in poor gestational outcome. This review covers recent data concerning thrombophilia and vascular placental pathology, and discusses available therapeutic modalities to prevent placental vascular thrombosis and maximize successful gestational outcome.
منابع مشابه
Thrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History
Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...
متن کاملRecurrent Pregnancy Loss in a Subject with Heterozygote Factor V Leiden Mutation; a Case Report
Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is cons...
متن کاملPregnancy and Thrombophilia
Thrombophilic disorders encompass a diverse group of coagulation disorders that potentiate a predisposition for thrombotic events (e.g. deep vein thrombosis and pulmonary embolism). The term thrombophilia was coined in 1965 following a Norwegian familial study of venous thrombosis [1]. The entity of thrombophilia has also been described as a disorder in which there is abnormally, enhanced coagu...
متن کاملInherited thrombophilia: a double-edged sword.
Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not ...
متن کاملAntithrombotic therapy for pregnancy loss.
BACKGROUND Although an association between thrombophilia and pregnancy loss has been observed in many studies, little is known about the pathophysiological mechanisms behind this association. Considering the association between thrombophilia and pregnancy loss, the efficacy of antithrombotic therapy for women with pregnancy loss (with or without thrombophilia) has been studied for the past 30 y...
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